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Stimulation of gastric acid production by vagal impulses involves an M-cholinoceptor subtype (M1-receptor), probably associated with enterochromaffin cells. Pirenzepine displays a preferential affinity for this receptor subtype. Remarkably, the HCl-secreting parietal cells possess only M3-receptors.
In order to maintain body temperature at its physiological level, excess heat must be dissipated—the patients have a hot skin and are sweating. The hypothalamic temperature controller (B1) can be inactivated by neuroleptics (p. 236), without impairment of other centers. Thus, it is possible to lower a patient’s body temperature without activating counter-regulatory mechanisms. |
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