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Targeted therapeutic suppression of viral replication requires selective inhibition of those metabolic processes that specifically serve viral replication in infected cells. To date, this can be achieved only to a limited extent. Viral replication as exemplified by Herpes simplex viruses (A):
The degree of fluctuation in plasma level over a given dosing interval can be reduced by use of a dosage form permitting slow (sustained) release (p. 10). The time required to reach steadystate accumulation during multiple constant dosing depends on the rate of elimination. As a rule of thumb, a plateau is reached after approximately three elimination half-lives (t1/2). |
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