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In principle, responsivity can be decreased by inhibiting excitatory or activating inhibitory neurons. Most excitatory nerve cells utilize glutamate and most inhibitory neurons utilize ?-aminobutyric acid (GABA) as their transmitter.
As blood flow is diminished, diffusion from the endoneural space into the capillary blood decreases because the critical concentration gradient between endoneural space and blood quickly becomes small when inflow of drug-free blood is reduced. |
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