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Protection from mosquito bites (net, skin-covering clothes, etc. ) is a very important prophylactic measure. Antimalarial therapy employs the same agents and is based on the same principles. The blood-schizonticidal halofantrine is reserved for therapy only. The pyrimethamine-sulfadoxine combination may be used for initial selftreatment.
Cephalosporins are acid stable, but many are poorly absorbed. Because they must be given parenterally, most—including those with high activity—are used only in clinical settings. A few, e. g. , cephalexin, are suitable for oral use. Cephalosporins are penicillinase-resistant, but cephalosporinase-forming organisms do exist.

 

Due to their penicillinase resistance, isoxazolylpenicillins (oxacillin dicloxacillin, flucloxacillin) are suitable for the (oral) treatment of infections caused by penicillinaseproducing staphylococci. (3) Extended activity spectrum: The aminopenicillin amoxicillin is active against many gramnegative organisms, e. g. , coli bacteria or Salmonella typhi.
When new vesicles are pinched off, substances dissolved in the extracellular fluid are engulfed, and then ferried through the cytoplasm, vesicles (phagosomes) undergo fusion with lysosomes to form phagolysosomes, and the transported substance is metabolized.

 

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