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Amantadine (C) specifically affects the replication of influenza A (RNA) viruses, the causative agent of true influenza. These viruses are endocytosed into the cell. Release of viral DNA requires protons from the acidic content of endosomes to penetrate the virus.
Food intake and physical activity (increased glucose uptake into musculature, decreased insulin demand) are accompanied by corresponding changes in insulin secretion (A, left track).

 

The effect declines only when the plasma level has returned (below 20) into the range where a change in plasma level causes a change in the intensity of the effect. The dose dependence of the time course of the drug effect is exploited when the duration of the effect is to be prolonged by administration of a dose in excess of that required for the effect.
Bronchial asthma: Increased sympathetic activity prevents bronchospasm in patients disposed to paroxysmal constriction of the bronchial tree (bronchial asthma, bronchitis in smokers). In this condition, ?2-receptor blockade will precipitate acute respiratory distress (B).

 

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