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When this is not possible, attempts can be made to slow tumor growth and thereby prolong the patient’s life or improve quality of life (palliative therapy). Chemotherapy is faced with the problem that the malignant cells are endogenous and are not endowed with special metabolic properties. Cytostatics (A) are cytotoxic substances that particularly affect proliferating or dividing cells.
The effect of ACh elicited at receptors on the ganglionic neuronal membrane can be imitated by nicotine; i.e., it involves nicotinic cholinoceptors. Ganglionic action of nicotine. If a small dose of nicotine is given, the ganglionic cholinoceptors are activated. The membrane depolarizes partially, but fails to reach the firing threshold.

 

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