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CAH catalyzes CO2 hydration/ dehydration reactions: H+ + HCO3 –-H2CO3-H20 + CO2. The enzyme is used in tubule cells to generate H+, which is secreted into the tubular fluid in exchange for Na+. There, H+ captures HCO3 –, leading to formation of CO2 via the unstable carbonic acid. Membrane-permeable CO2 is taken up into the tubule cell and used to regenerate H+ and HCO3 –.
Among the multiple functions of the endothelium, the production of NO? and prostacyclin plays an important role. Both substances inhibit the tendency of platelets to adhere to the endothelial surface (platelet adhesiveness).

 

Neuromuscular transmission (B) of motor nerve impulses to the striated muscle fiber takes place at the motor endplate. The nerve impulse liberates acetylcholine (ACh) from the axon terminal. ACh binds to nicotinic cholinoceptors at the motor endplate.
At dosages below those needed to treat malignancies, some cytostatics are also employed for immunosuppression, e. g. , azathioprine, methotrexate, and cyclophosphamide. The antiproliferative effect is not specific for lymphocytes and involves both T- and Bcells. Mycophenolate mofetil has a more specific effect on lymphocytes than on other cells.

 

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