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Under certain conditions, drug can also be applied percutaneously in the form of a transdermal delivery system. In this case, drug is slowly released from the reservoir, and then penetrates the epidermis and subepidermal connective tissue where it enters blood capillaries. Only a very few drugs can be applied transdermally.
Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including Mycoplasma and legionellosis.

 

Reteplase, however, containing only the proteolytic active part of the alteplase molecule, allows more stabile plasma levels and can be applied in form of two injections at an interval of 30 min. Inactivation of the fibrinolytic system can be achieved by “plasmin inhibitors,” such as aminocaproic acid, p-aminomethylbenzoic acid, tranexamic acid, and aprotinin, which also inhibits other proteases.
A constant plasma level would, however, be undesirable if it accelerated a loss of effectiveness (development of tolerance), or if the drug were required to be present at specified times only.

 

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