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Pantoprazole (Protonix) is in a class of drugs called proton pump inhibitors (PPI) which block the production of acid by the stomach. Other drugs in the same class include Lansoprazole (Prevacid), Omeprazole (Prilosec) and Rabeprazole (Aciphex). Proton pump inhibitors are used for the treatment of conditions such as ulcers, gastroesophageal reflux disease and Zollinger-Ellison syndrome that are caused by stomach acid.
linical studies In vivo studies have been performed on oral fast-disintegrating dosage forms to investigate their behavior in the oral–esophageal tract, their pharmacokinetic and therapeutic efficacy, and acceptability. Zydis’s residence time in the mouth and stomach, and its transit through the esophageal tract, was investigated using gamma-scintigraphy.

 

Rarely life-threatening, poisoning with atropine is characterized by the following peripheral and central effects: Peripheral: tachycardia; dry mouth; hyperthermia secondary to the inhibition of sweating. Although sweat glands are innervated by sympathetic fibers, these are cholinergic in nature.
The evaluation of a dose-effect relationship within a group of human subjects is compounded by interindividual differences in sensitivity. To account for the biological variation, measurements have to be carried out on a representative sample and the results averaged. Thus, recommended therapeutic doses will be appropriate for the majority of patients, but not necessarily for each individual.

 

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