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This change propagates to the G-protein: the ?-subunit exchanges GDP for GTP, then dissociates from the two other subunits, associates with an effector protein, and alters its functional state. The ?-subunit slowly hydrolyzes bound GTP to GDP. G?-GDP has no affinity for the effector protein and reassociates with the ? and ? subunits (A).

 

According to the chemical structure of the side chain, phenothiazines and thioxanthenes can be subdivided into aliphatic (chlorpromazine, triflupromazine, p. 239 and piperazine congeners (trifluperazine, fluphenazine, flupentixol, p. 239). The antipsychotic effect is probably due to an antagonistic action at dopamine receptors.
The severity of these and other adverse reactions (e. g. , rage, violent hostility, hallucinations), and their increased frequency in the elderly, has led to curtailed or suspended use of triazolam in some countries (UK).

 

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