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Substances with a long half-life are preferable for long-term anxiolytic treatment (light green area) because they permit maintenance of steady plasma levels with single daily dosing. Midazolam enjoys use by the i. v. route in preanesthetic medication and anesthetic combination regimens. Benzodiazepine Dependence Prolonged regular use of benzodiazepines can lead to physical dependence.
Closely related chemically to amphetamine are the so-called appetite suppressants or anorexiants, such as fenfluramine, mazindole, and sibutramine. These may also cause dependence and their therapeutic value and safety are questionable.

 

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Drugs used to counteract drug overdosage are considered under the appropriate headings, e. g. , physostigmine with atropine; naloxone with opioids; flumazenil with benzodiazepines; antibody (Fab fragments) with digitalis; and N-acetyl-cysteine with acetaminophen intoxication. Chelating agents (A) serve as antidotes in poisoning with heavy metals.

 

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