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Combustion of tobacco generates approx. 4000 chemical compounds in detectable quantities. The xenobiotic burden on the smoker depends on a range of parameters, including tobacco quality, presence of a filter, rate and temperature of combustion, depth of inhalation, and duration of breath holding. Tobacco contains 0.2–5 % nicotine.
Conceivably, adaptive processes (such as downregulation of cortical serotonin and ?-adrenoceptors) are ultimately responsible. In healthy subjects, the TCAs do not improve mood (no euphoria). Apart from the antidepressant effect, acute effects occur that are evident also in healthy individuals. |
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