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Dependence on them has all the characteristics of an addiction. Because of rapidly developing tolerance, choral hydrate is suitable only for short-term use. Antihistamines are popular as nonprescription (over-the-counter) sleep remedies (e. g. , diphenhydramine, doxylamine, p. 114), in which case their sedative side effect is used as the principal effect.
A possible explanation is that both agents already interfere with elements of ADP receptor signal transduction at the megakaryocytic stage. The ensuing functional defect would then be transmitted to newly formed platelets, which would be incapable of reversing it. The intra-platelet levels of cAMP can be stabilized by prostacyclin or its analogues (e. g. , iloprost) or by dipyridamole. |
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