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he common feature of diseasemodifiers is their delayed effect, which develops only after treatment for several weeks. Among possible mechanisms of action, inhibition of macrophage activity and inhibition of release or activity of lysosomal enzymes are being discussed.
It needs to be assessed to give an insight into the disintegration properties of the tablets; a lower wetting time implies a quicker disintegration of the tablet. For this purpose, a tablet is placed on a piece of tissue paper folded twice and kept in a small Petri dish (ID = 6. 5 cm) containing 6 ml of water, and the time for complete wetting is measured39.

 

When the drug is applied to the oral mucosa (buccal, sublingual route), plasma levels rise faster than with conventional oral administration because the drug preparation is deposited at its actual site of absorption and very high concentrations in saliva occur upon the dissolution of a single dose. Thus, uptake across the oral epithelium is accelerated.
Citalopram is an antidepressant medication that affects neurotransmitters, the chemicals that nerves within the brain use to communicate with each other. Neurotransmitters are manufactured and released by nerves and then travel and attach to nearby nerves. Thus, neurotransmitters can be thought of as the communication system of the brain.

 

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