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he common feature of diseasemodifiers is their delayed effect, which develops only after treatment for several weeks. Among possible mechanisms of action, inhibition of macrophage activity and inhibition of release or activity of lysosomal enzymes are being discussed.
When the drug is applied to the oral mucosa (buccal, sublingual route), plasma levels rise faster than with conventional oral administration because the drug preparation is deposited at its actual site of absorption and very high concentrations in saliva occur upon the dissolution of a single dose. Thus, uptake across the oral epithelium is accelerated. |
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