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Infections due to fungi are usually confined to the skin or mucous membranes: local or superficial mycosis. However, in immune deficiency states, internal organs may also be affected: systemic or deep mycosis. Mycoses are most commonly due to dermatophytes, which affect the skin, hair, and nails following external infection.
Promethazine represents the transition to the neuroleptic phenothiazines. Unwanted effects of most H1-antihistamines are lassitude (impaired driving skills) and atropine- like reactions (e.g., dry mouth, constipation). At the usual therapeutic doses, astemizole, cetrizine, fexofenadine, and loratidine are practically devoid of sedative and anticholinergic effects.

 

The enteric musculature reacts with increased peristalsis. The aims of antidiarrheal therapy are to prevent: (1) dehydration and electrolyte depletion; and (2) excessively high stool frequency. Different therapeutic approaches (in green) listed are variously suited for these purposes. Adsorbent powders are nonabsorbable materials with a large surface area.
Both hydroxyl groups on the aromatic nucleus contribute to affinity; high activity at ?-receptors is associated with hydroxyl groups at the 3 and 4 positions. Affinity for ?-receptors is preserved in congeners bearing hydroxyl groups at positions 3 and 5 (orciprenaline, terbutaline, fenoterol).

 

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