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In older patients with goiter due to iodine deficiency there is a risk of provoking hyperthyroidism by increasing iodine intake: During chronic maximal stimulation, thyroid follicles can become independent of TSH stimulation (“autonomic tissue”). If the iodine supply is increased, thyroid hormone production increases while TSH secretion decreases due to feedback inhibition.
At higher concentrations, nicotine acts to block ganglionic transmission. Simultaneous activation of many nicotinic cholinoceptors depolarizes the ganglionic cell membrane to such an extent that generation of action potentials is no longer possible, even in the face of an intensive and synchronized release of ACh (C).

 

Purine (cell nuclei)-rich foods should be avoided, e. g. , organ meats. Milk, dairy products, and eggs are low in purines and are recommended. Coffee and tea are permitted since the methylxanthine caffeine does not enter purine metabolism. Uricostatics decrease urate production.
PGE2 and PGI2 produce arteriolar vasodilation; PGF2?, venoconstriction. Gastric secretion. PG promote the production of gastric mucus and reduce the formation of gastric acid (p. 160). Menstruation. PGF2? is believed to be responsible for the ischemic necrosis of the endometrium preceding menstruation.

 

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