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Consequently, the molecular weight of dextran circulating in blood will tend towards a higher mean molecular weight with the passage of time. The most important adverse effect results from the antigenicity of dextrans, which may lead to an anaphylactic reaction. Hydroxyethyl starch (hetastarch) is produced from starch.
Trazodone is an antidepressant medication. It is thought to increase the activity of one of the brain chemicals (serotonin) which may become unbalanced and cause depression. Trazodone is used to treat depression. It may also be used for relief of anxiety disorders (eg, sleeplessness, tension) and chronic pain. Trazodone may also be used for other purposes not listed in this medication guide.

 

During electrical excitation of the cell membrane of heart or smooth muscle, different ionic currents are activated, including an inward Ca2+ current. The term Ca2+ antagonist is applied to drugs that inhibit the influx of Ca2+ ions without affecting inward Na+ or outward K+ currents to a significant degree. Other labels are Ca-entry blocker or Ca-channel blocker.
Therapeutic uses. Because of their narrow therapeutic margin, these antiarrhythmics are only employed when rhythm disturbances are of such severity as to impair the pumping action of the heart, or when there is a threat of other complications. The choice of drug is empirical. If the desired effect is not achieved, another drug is tried. Combinations of antiarrhythmics are not customary.

 

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