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The substances listed below are useful as antibacterial drugs because they do not affect human cells. Gyrase inhibitors. The enzyme gyrase (topoisomerase II) permits the orderly accommodation of a ~1000 ?mlong bacterial chromosome in a bacterial cell of ~1 ?m. Within the chromosomal strand, double-stranded DNA has a double helical configuration.
It is well tolerated; however, released Al3+ ions can cause constipation. Misoprostol (B) is a semisynthetic prostaglandin derivative with greater stability than natural prostaglandin, permitting absorption after oral administration. Like locally released prostaglandins, it promotes mucus production and inhibits acid secretion. |
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