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Although benzodiazepines are well tolerated, the possibility of personality changes (nonchalance, paradoxical excitement) and the risk of physical dependence with chronic use must not be overlooked. Conceivably, benzodiazepine dependence results from a kind of habituation, the functional counterparts of which become manifest during abstinence as restlessness and anxiety; even seizures may occur.
Tetrahydrofolic acid (THF) is a co-enzyme in the synthesis of purine bases and thymidine. These are constituents of DNA and RNA and required for cell growth and replication. Lack of THF leads to inhibition of cell proliferation. Formation of THF from dihydrofolate (DHF) is catalyzed by the enzyme dihydrofolate reductase.

 

Hydroxocobalamin is an alternative, very effective antidote because its central cobalt atom binds CN- with high affinity to generate cyanocobalamin. Tolonium chloride (Toluidin Blue). Brown-colored methemoglobin, containing tri- instead of divalent iron, is incapable of carrying O2.
ACE is also present in blood plasma; however, enzyme localized in the luminal side of vascular endothelium is primarily responsible for the formation of angiotensin II. The lung is rich in ACE, but kidneys, heart, and other organs also contain the enzyme. Angiotensin II can raise blood pressure in different ways, including vasoconstriction in both the arterial and venous limbs of the circulation;

 

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