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Prior to its uptake into the blood (i.e., during absorption), a drug has to overcome barriers that demarcate the body from its surroundings, i.e., separate the internal milieu from the external milieu. These boundaries are formed by the skin and mucous membranes.
Like ASA, these substances have analgesic, antipyretic, and antiinflammatory activity. In contrast to ASA, they inhibit cyclooxygenase in a reversible manner. Moreover, they are not suitable as inhibitors of platelet aggregation. Since their desired effects are similar, the choice between NSAIDs is dictated by their pharmacokinetic behavior and their adverse effects.

 

The plasmalemma of cardiomyocytes extends into the cell interior in the form of tubular invaginations (transverse tubuli). The trigger signal for relaxation is the return of the membrane potential to its resting level.
Several substances that are employed as bronchodilators are described elsewhere in more detail: ?2-sympathomimetics (given by pulmonary, parenteral, or oral route), the methylxanthine theophylline (given parenterally or orally), as well as the parasympatholytic ipratropium. Spasmolytics. N-Butylscopolamine is used for the relief of painful spasms of the biliary or ureteral ducts.

 

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