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The assignment of specific receptor subtypes to these functions has yet to be achieved. In blood vessels, the relaxant action of ACh on muscle tone is indirect, because it involves stimulation of M3-cholinoceptors on endothelial cells that respond by liberating NO (= endotheliumderived relaxing factor).
Pathophysiology. One of the main pathogenetic factors is an allergic inflammation of the bronchial mucosa. For instance, leukotrienes that are formed during an IgE-mediated immune response exert a chemotactic effect on inflammatory cells. As the inflammation develops, bronchi become hypersensitive to spasmogenic stimuli. |
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