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This self-digestion occurs when the equilibrium between the corrosive hydrochloric acid and acid-neutralizing mucus, which forms a protective cover on the mucosal surface, is shifted in favor of hydrochloric acid. Mucosal damage can be promoted by Helicobacter pylori bacteria that colonize the gastric mucus.
Its symptoms, sneezing, running nose (due to rhinitis), hoarseness (laryngitis), difficulty in swallowing and sore throat (pharyngitis and tonsillitis), cough associated with first serous then mucous sputum (tracheitis, bronchitis), sore muscles, and general malaise can be present individually or concurrently in varying combination or sequence.

 

The exact cause of these complaints is unknown; however, a disturbance in cranial blood flow is the likely underlying pathogenetic mechanism. In addition to an often inherited predisposition, precipitating factors are required to provoke an attack, e. g. , psychic stress, lack of sleep, certain foods.
According to the chemical structure of the side chain, phenothiazines and thioxanthenes can be subdivided into aliphatic (chlorpromazine, triflupromazine, p. 239 and piperazine congeners (trifluperazine, fluphenazine, flupentixol, p. 239). The antipsychotic effect is probably due to an antagonistic action at dopamine receptors.

 

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