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The endogenous male gonadal hormone is the steroid testosterone from the interstitial Leydig cells of the testis. Testosterone secretion is stimulated by hypophyseal luteinizing hormone (LH), whose release is controlled by hypothalamic GnRH (gonadorelin). Release of both hormones is subject to feedback inhibition by circulating testosterone.
A delayed efflux of K+ returns the membrane potential (Phase 3, repolarization) to its resting value (Phase 4). The velocity of depolarization determines the speed at which the AP propagates through the myocardial syncytium. Transmembrane ionic currents involve proteinaceous membrane pores: Na+, Ca2+, and K+ channels. |
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