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In order to maintain body temperature at its physiological level, excess heat must be dissipated—the patients have a hot skin and are sweating. The hypothalamic temperature controller (B1) can be inactivated by neuroleptics (p. 236), without impairment of other centers. Thus, it is possible to lower a patient’s body temperature without activating counter-regulatory mechanisms.
Owing to the fatty acid nature of undecanoic acid, this ester is absorbed into the lymph, enabling it to bypass the liver and enter, via the thoracic duct, the general circulation. 17-a Methyltestosterone is effective by the oral route due to its increased metabolic stability, but because of the hepatotoxicity of C17-alkylated androgens (cholestasis, tumors) its use should be avoided.

 

Hydrolysis is catalyzed by “angiotensin- converting enzyme” (ACE). Peptide analogues such as captopril (p. 124) block this enzyme. Angiotensin II is degraded by angiotensinase A, which clips off the N-terminal asparagine residue. The product, angiotensin III, lacks vasoconstrictor activity.
The uterine relaxant effect of ?2-adrenoceptor agonists, such as terbutaline or fenoterol, can be used to prevent premature labor. Vasodilation with a resultant drop in systemic blood pressure results in reflex tachycardia, which is also due in part to the ?1-stimulant action of these drugs. Cardiostimulation.

 

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