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Various scientists41 have developed new in vitro methods that allow an accurate determination of disintegration test. The disintegration test is performed using a texture analyzer instrument. In this test, a flat-ended cylindrical probe penetrates into the disintegrating tablet immersed in water.
In the case of primary or secondary amines, dealkylation of an alkyl group starts at the carbon adjacent to the nitrogen; in the case of tertiary amines, with hydroxylation of the nitrogen (e. g. , lidocaine). The intermediary products are labile and break up into the dealkylated amine and aldehyde of the alkyl group removed. |
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