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Statistics also show that, on cessation of smoking, the increased risk of death from coronary infarction or other cardiovascular disease declines over 5–10 years almost to the level of non-smokers. Similarly, the risk of developing bronchial carcinoma is reduced. Abrupt cessation of regular smoking is not associated with severe physical withdrawal symptoms.
The effectiveness of such indirect sympathomimetics diminishes or disappears (tachyphylaxis) when vesicular stores of NE close to the axolemma are depleted. Indirect sympathomimetics can penetrate the blood-brain barrier and evoke such CNS effects as a feeling of well-being, enhanced physical activity and mood (euphoria), and decreased sense of hunger or fatigue. |
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