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Simultaneous binding of two acetylcholine (ACh) molecules to the two ?-subunits results in opening of the ion channel, with entry of Na+ (and exit of some K+), membrane depolarization, and triggering of an action potential (p. 82). The ganglionic N-cholinoceptors apparently consist only of ? and ? subunits (?2?2).
Finally, signalling substances can originate from neighboring cells, e.g., prostaglandins and cytokines. The effect of a drug frequently results from interference with cellular function. Receptors for the recognition of endogenous transmitters are obvious sites of drug action (receptor agonists and antagonists. |
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