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Whereas benzodiazepines possessing agonist activity indirectly augment chloride permeability, inverse agonists exert an opposite action. These substances give rise to pronounced restlessness, excitement, anxiety, and convulsive seizures. There is, as yet, no therapeutic indication for their use.
Ionic interaction: An ion is a particle charged either positively (cation) or negatively (anion), i. e. , the atom lacks or has surplus electrons, respectively. Attraction between ions of opposite charge is inversely proportional to the square of the distance between them; it is the initial force drawing a charged drug to its binding site. |
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