Drug Name Tribulus

Inhibition of the enzyme causes free NE concentrations to rise. Likewise, dopamine catabolism is impaired, making more of it available for NE synthesis. Consequently, the amount of NE stored in granular vesicles will increase, and with it the amount of amine released per nerve impulse. In the CNS, inhibition of MAO affects neuronal storage not only of NE but also of dopamine and serotonin.
Tetracyclines are absorbed from the gastrointestinal tract to differing degrees, depending on the substance, absorption being nearly complete for doxycycline and minocycline. Intravenous injection is rarely needed (rolitetracycline is available only for i. v. administration).

 

Besides the Na+ channel, Ca2+ and K+ channels are also likely to be blocked. Accordingly, cationic amphiphilic antiarrhythmics affect both the depolarization and repolarization phases. Depending on the substance, AP duration can be increased (Class IA), decreased (Class IB), or remain the same (Class IC).
On the basis of these parameters, differences between drugs can be quantified. As a rule, the therapeutic effect or toxic action depends critically on the response of a single organ or a limited number of organs, e. g. , blood flow is affected by a change in vascular luminal width.