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In pacemaker fibers, diastolic depolarization is hastened, so that the firing threshold for the action potential is reached sooner (positive chronotropic effect, B). The cardiostimulant effect of ?-sympathomimetics such as epinephrine is exploited in the treatment of cardiac arrest. Use of ?- sympathomimetics in heart failure carries the risk of cardiac arrhythmias.
Change in site of action: e. g. , increased synthesis of dihydrofolate reductase may occur as a compensatory response to methotrexate. Damage repair: DNA repair enzymes may become more efficient in repairing defects caused by cisplatin. Both the prevention of transplant rejection and the treatment of autoimmune disorders call for a suppression of immune responses.

 

Benzocaine (ethoform) is a member of the group of local anesthetics lacking a nitrogen that can be protonated at physiological pH. It is used exclusively as a surface anesthetic. Other agents employed for surface anesthesia include the uncharged polidocanol and the catamphiphilic cocaine, tetracaine, and lidocaine. Source of opioids. Morphine is an opium alkaloid.
This reaction can be observed after the application of ?-sympathomimetics (naphazoline, tetrahydrozoline, xylometazoline) to the nasal mucosa. Initially, vasoconstriction reduces mucosal blood flow and, hence, capillary pressure. Fluid exuded into the interstitial space is drained through the veins, thus shrinking the nasal mucosa.

 

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