Drug Name Levlen

Rheumatoid arthritis or chronic polyarthritis is a progressive inflammatory joint disease that intermittently attacks more and more joints, predominantly those of the fingers and toes.
Lipophilic substances (red dots) may enter the membrane from the extracellular space (area shown in ochre), accumulate in the membrane, and exit into the cytosol (blue area). Direction and speed of permeation depend on the relative concentrations in the fluid phases and the membrane. The steeper the gradient (concentration difference), the more drug will be diffusing per unit of time.

 

Discontinuance of hormone administration would be followed by menstruation. The physiological time course of estrogen- progesterone release is simulated in the so-called biphasic (sequential) preparations (A). In monophasic preparations, estrogen and progestin are taken concurrently.
Unwanted effects. Hypoglycemia results from absolute or relative overdosage. Allergic reactions are rare—locally: redness at injection site, atrophy of adipose tissue (lipodystrophy); systemically: urticaria, skin rash, anaphylaxis. Insulin resistance can result from binding to inactivating antibodies. A possible local lipohypertrophy can be avoided by alternating injection sites.