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(However, in pharmacological experiments on isolated cardiac muscle preparations a clear negative inotropic effect is demonstrable.) They are thus regarded as vasoselective Ca2+ antagonists. Because of the dilatation of resistance vessels, blood pressure falls. Cardiac afterload is diminished and, therefore, also oxygen demand. Spasms of coronary arteries are prevented.
Therapy of congestive heart failure. By lowering peripheral resistance, diuretics aid the heart in ejecting blood (reduction in afterload, pp. 132, 306); cardiac output and exercise tolerance are increased. Due to the increased excretion of fluid, EFV and venous return decrease (reduction in preload, p. 306). Symptoms of venous congestion, such as ankle edema and hepatic enlargement, subside.

 

Pantoprazole (Protonix) is in a class of drugs called proton pump inhibitors (PPI) which block the production of acid by the stomach. Other drugs in the same class include Lansoprazole (Prevacid), Omeprazole (Prilosec) and Rabeprazole (Aciphex). Proton pump inhibitors are used for the treatment of conditions such as ulcers, gastroesophageal reflux disease and Zollinger-Ellison syndrome that are caused by stomach acid.
Rifampin is frequently given in combination with one or both of the following agents: Dapsone is a sulfone that, like sulfonamides, inhibits dihydrofolate synthesis (p. 272). It is bactericidal against susceptible strains of M. leprae. Dapsone is given orally. The most frequent adverse effect is methemoglobinemia with accelerated erythrocyte degradation (hemolysis).

 

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