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With oral administration of pancreatic enzymes, allowance must be made for their partial inactivation by gastric acid (the lipases, particularly). Therefore, they are administered in acid-resistant dosage forms. Antiflatulents (carminatives) serve to alleviate meteorism (excessive accumulation of gas in the gastrointestinal tract).
In other cases, a fixed-dosage schedule will be needed, e. g. , morning and evening injections of a combination insulin in constant respective dosage (A). To avoid hypo- or hyperglycemias with this regimen, dietary carbohydrate (CH) intake must be synchronized with the time course of insulin absorption from the s. c. depot.

 

Physiologically, this mucociliary transport functions to remove inspired dust particles.
The seven ?-helical membrane-spanning domains probably form a circle around a central pocket that carries the attachment sites for the mediator substance. Binding of the mediator molecule or of a structurally related agonist molecule induces a change in the conformation of the receptor protein, enabling the latter to interact with a G-protein (= guanyl nucleotide-binding protein).

 

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