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Since there is delayed gastric emptying during the attack, drug absorption can be markedly retarded, hence effective plasma levels are not obtained. Because metoclopramide stimulates gastric emptying, it promotes absorption of ingested analgesic drugs and thus facilitates pain relief. If acetylsalicylic acid is administered i. v. as the lysine salt, its bioavailability is complete.
With oral administration of pancreatic enzymes, allowance must be made for their partial inactivation by gastric acid (the lipases, particularly). Therefore, they are administered in acid-resistant dosage forms. Antiflatulents (carminatives) serve to alleviate meteorism (excessive accumulation of gas in the gastrointestinal tract).

 

However, a plasma substitute need not contain plasma proteins. These can be suitably replaced with macromolecules (“colloids”) that, like plasma proteins, (1) do not readily leave the circulation and are poorly filtrable in the renal glomerulus; and (2) bind water along with its solutes due to their colloid osmotic properties.
In the diabetic, insulin could be administered as it is normally secreted; that is, injection of short-acting insulin before each main meal plus bedtime administration of a Lente preparation to avoid a nocturnal shortfall of insulin. This regimen requires a well-educated, cooperative, and competent patient.

 

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