Drug Name Citalopram

Side effects. Lassitude, dry mouth; rebound hypertension after abrupt cessation of clonidine therapy. Methyldopa (dopa = dihydroxyphenylalanine), as an amino acid, is transported across the blood-brain barrier, decarboxylated in the brain to ?- methyldopamine, and then hydroxylated to ?-methyl-NE.
The antihypertensive agents, reserpine (obsolete) and ?-methyldopa, deplete neuronal stores of the amine. A common adverse effect of dopamine antagonists or depletors is parkinsonism. Histamine (B).Histamine is stored in basophils and tissue mast cells.

 

One drug may displace another from its binding site and thereby elevate the free (effective) concentration of the displaced drug (a form of drug interaction). Elevation of the free concentration of the displaced drug means increased effectiveness and ccelerated elimination.
The characteristic phasic time course of drug concentration in plasma represents the sum of the constituent processes of absorption, distribution, and elimination, which overlap in time.