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With continued exposure, induction develops in a few days, resulting in an increase in reaction velocity, maximally 2–3fold, that disappears after removal of the inducing agent. Many drugs undergo chemical modification in the body (biotransformation).
Dopamine is not to be confused with dobutamine which stimulates ?- and ?-adrenoceptors but not dopamine receptors. Dopamine-mimetics. Administration of the precursor L-dopa promotes endogenous synthesis of dopamine (indication: parkinsonian syndrome.

 

Thus, reabsorption of NaCl and water is inhibited. Renal excretion of Ca2+ decreases, that of Mg2+ increases. Indications are hypertension, cardiac failure, and mobilization of edema.
The topically active allylamine naftidine and the morpholine amorolfine also inhibit ergosterol synthesis, albeit at another step. The polyene antibiotics, amphotericin B and nystatin, are of bacterial origin. They insert themselves into fungal cell membranes (probably next to ergosterol molecules) and cause formation of hydrophilic channels.

 

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