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With continued exposure, induction develops in a few days, resulting in an increase in reaction velocity, maximally 2–3fold, that disappears after removal of the inducing agent. Many drugs undergo chemical modification in the body (biotransformation).
Thus, reabsorption of NaCl and water is inhibited. Renal excretion of Ca2+ decreases, that of Mg2+ increases. Indications are hypertension, cardiac failure, and mobilization of edema. |
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