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Accordingly, for protonated substances, the extent of reabsorption is dependent upon urinary pH or the degree of dissociation. The degree of dissociation varies as a function of the urinary pH and the pKa, which represents the pH value at which half of the substance exists in protonated (or unprotonated) form.
When bacteria are in their growth and replication phase, penicillins are bactericidal; due to cell wall defects, the bacteria swell and burst. Penicillins are generally well tolerated; with penicillin G, the daily dose can range from approx. 0. 6 g i. m. (= 106 international units, 1 Mega I. U. ) to 60 g by infusion. |
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