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Hence, the duration of the effect depends on the rate of enzyme resynthesis. Furthermore, salicylate may contribute to the effect. ASA irritates the gastric mucosa (direct acid effect and inhibition of cytoprotective PG synthesis, p. 200) and can precipitate bronchoconstriction (“aspirin asthma,” pseudoallergy) due to inhibition of PGE2 synthesis and overproduction of leukotrienes.
Agents for chemical disinfection ideally should cause rapid, complete, and persistent inactivation of all germs, but at the same time exhibit low toxicity (systemic toxicity, tissue irritancy, antigenicity) and be non-deleterious to inanimate materials. These requirements call for chemical properties that may exclude each other; therefore, compromises guided by the intended use have to be made.

 

When sweating is inhibited due to poisoning with anticholinergics (e. g. , atropine), cutaneous blood flow increases. If insufficient heat is dissipated through this route, overheating occurs (hyperthermia). Thyroid hyperfunction poses a particular challenge to the thermoregulatory system, because the excessive secretion of thyroid hormones causes metabolic heat production to increase.
Rifampin inhibits the bacterial enzyme that catalyzes DNA template-directed RNA transcription, i. e. , DNA-dependent RNA polymerase. Rifampin acts bactericidally against mycobacteria (M. tuberculosis, M. leprae), as well as many gram-positive and gram-negative bacteria. It is well absorbed after oral ingestion.

 

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