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Hence, the duration of the effect depends on the rate of enzyme resynthesis. Furthermore, salicylate may contribute to the effect. ASA irritates the gastric mucosa (direct acid effect and inhibition of cytoprotective PG synthesis, p. 200) and can precipitate bronchoconstriction (“aspirin asthma,” pseudoallergy) due to inhibition of PGE2 synthesis and overproduction of leukotrienes.
When sweating is inhibited due to poisoning with anticholinergics (e. g. , atropine), cutaneous blood flow increases. If insufficient heat is dissipated through this route, overheating occurs (hyperthermia). Thyroid hyperfunction poses a particular challenge to the thermoregulatory system, because the excessive secretion of thyroid hormones causes metabolic heat production to increase. |
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