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On the injured endothelial cell, a platelet thrombus is formed, which obstructs blood flow. Ultimately, the vascular lumen is occluded by the thrombus as the latter is solidified by a vasoconstriction produced by the release of serotonin and thromboxane A2 from the aggregated platelets.
Nowadays, it is known that intoxication from intestinal substances is impossible as long as the liver functions normally. Nonetheless, purgatives continue to be sold as remedies to “cleanse the blood” or to rid the body of “corrupt humors. ” There can be no objection to the ingestion of bulk substances for the purpose of supplementing low-residue “modern diets.

 

Administration of levodopa plus carbidopa (or benserazide) remains the most effective treatment, but does not provide benefit beyond 3–5 y and is followed by gradual loss of symptom control, on-off fluctuations, and development of orobuccofacial and limb dyskinesias. These long-term drawbacks of levodopa therapy may be delayed by early monotherapy with dopamine receptor agonists.
The exact cause of these complaints is unknown; however, a disturbance in cranial blood flow is the likely underlying pathogenetic mechanism. In addition to an often inherited predisposition, precipitating factors are required to provoke an attack, e. g. , psychic stress, lack of sleep, certain foods.

 

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