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The former activates adenyl cyclase via a G-protein-coupled receptor; the latter inhibits a phosphodiesterase that breaks down cAMP. The integrin (GPIIB/IIIA)-antagonists prevent cross-linking of platelets. Their action is independent of the aggregation- inducing stimulus.
These receptors are coupled to Gq proteins that mediate activation of phospholipase C and hence a rise in cytosolic Ca2+ concentration. Among other responses, this rise in Ca2+ triggers a conformational change in GPIIB/IIIA, which is thereby converted to its fbrinogen-binding form. In contrast, ADP activates platelets by inhibiting adenylyl cyclase, thus causing internal cAMP levels to decrease. |
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