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Like ASA, these substances have analgesic, antipyretic, and antiinflammatory activity. In contrast to ASA, they inhibit cyclooxygenase in a reversible manner. Moreover, they are not suitable as inhibitors of platelet aggregation. Since their desired effects are similar, the choice between NSAIDs is dictated by their pharmacokinetic behavior and their adverse effects.
The determination of plasma levels affords a comparison of different proprietary preparations containing the same drug in the same dosage. Identical plasma level time-curves of different manufacturers’ products with reference to a standard preparation indicate bioequivalence of the preparation under investigation with the standard.

 

By tending towards each other, H2O molecules squeeze apolar particles from their midst. Accordingly, in the organism, apolar particles have an increased probability of staying in nonaqueous, apolar surroundings, such as fatty acid chains of cell membranes or apolar regions of a receptor.
Major effector proteins for G-protein- coupled receptors include adenylate cyclase (ATP intracellular messenger cAMP), phospholipase C (phosphatidylinositol intracellular messengers inositol trisphosphate and diacylglycerol), as well as ion channel proteins.

 

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