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At rest, the intracellular concentration of free calcium ions (Ca2+) is kept at 0. 1 ?M (see p. 128 for mechanisms involved). During excitation, a transient rise of up to 10 ?M elicits contraction in muscle cells (electromechanical coupling) and secretion in glandular cells (electrosecretory coupling).
HCG, human chorionic gonadotropin, from the urine of pregnant women, acts like LH. Anabolics are testosterone derivatives (e. g. , clostebol, metenolone, nandrolone, stanozolol) that are used in debilitated patients, and misused by athletes, because of their protein anabolic effect.

 

In concentrations needed for therapeutic fibrinolysis this preference is lost and the risk of bleeding does not differ with alteplase and streptokinase. Alteplase is rather shortlived (inactivation by complexing with plasminogen activator inhibitor, PAI) and has to be applied by infusion.
After a few milliseconds, the Na channels close automatically (“inactivation”), the membrane potential returns to resting levels, and the AP is terminated. As long as the membrane potential remains incompletely repolarized, renewed opening of Na channels, hence a new AP, is impossible.

 

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