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Small losses via the feces are made up by de novo synthesis in the liver, keeping the total amount of bile acids constant (3–5 g). Exogenous supply removes the need for de novo synthesis of bile acids. The particular acid being supplied gains an increasingly larger share of the total store. The altered composition of bile increases the capacity for cholesterol uptake.
The binding capacity of transferrin is limited and free Fe3+ is toxic. Therefore, Fe3+ complexes are employed that can donate Fe3+ directly to transferrin or can be phagocytosed by macrophages, enabling iron to be incorporated into ferritin stores.

 

When the oral route is unavailable opioids may be administered by continuous infusion (pump) and when appropriate under control by the patient – advantage: constant therapeutic plasma level; disadvantage: indwelling catheter. When constipation becomes intolerable morphin can be applied near the spinal cord permitting strong analgesic effect at much lower total dosage.
5 nm; the synaptic gap is as narrow as 30–40 nm). At the postsynaptic effector cell membrane, ACh reacts with its receptors. Because these receptors can also be activated by the alkaloid muscarine, they are referred to as muscarinic (M-)cholinoceptors.

 

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