Drug Name Erythromycin

Hypoglycemia in diabetes mellitus: When treatment with insulin or oral hypoglycemics in the diabetic patient lowers blood glucose below a critical level, epinephrine is released, which then stimulates hepatic glucose release via activation of ?2-receptors.
Because estrogen monotherapy increases the risk of uterine cancer, a gestagen needs to be given concurrently (except after hysterectomy), as e. g. , in an oral contraceptive preparation. Under this therapy, menses will continue. The risk of thromboembolic disorders is increased and that of myocardial infarction probably lowered.

 

Small portions of norepinephrine are inactivated by the enzyme catechol-O-methyltransferase (COMT, present in the cytoplasm of postjunctional cells, to yield normetanephrine), and monoamine oxidase (MAO, present in mitochondria of nerve cells and postjunctional cells, to yield 3,4-dihydroxymandelic acid).
Clofazimine is a dye with bactericidal activity against M. leprae and antiinflammatory properties. It is given orally, but is incompletely absorbed. Because of its high lipophilicity, it accumulates in adipose and other tissues and leaves the body only rather slowly (t1/2 ~ 70 d). Red-brown skin pigmentation is an unwanted effect, particularly in fair-skinned patients.