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The variation in sensitivity may be based on pharmacokinetic differences (same dose different plasma levels) or on differences in target organ sensitivity (same plasma level different effects). The relationship between the concentration of a drug and its effect is determined in order to define the range of active drug concentrations (potency) and the maximum possible effect (efficacy).
The tertiary carbamate physostigmine can be used as an antidote in poisoning with parasympatholytic drugs, because it has access to AChE in the brain. Carbamates (neostigmine, pyridostigmine, physostigmine) and organophosphates (paraoxon, ecothiopate) can also be applied locally to the eye in the treatment of glaucoma; however, their long-term use leads to cataract formation. |
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