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Its hormonal effect on protein synthesis leads to augmentation of the reabsorptive capacity of tubule cells. Spironolactone, as well as its metabolite canrenone, are antagonists at the aldosterone receptor and attenuate the effect of the hormone. The diuretic effect of spironolactone develops fully only with continuous administration for several days.
Whether mucolytics are indicated in the common cold and whether expectorants like bromohexine or ambroxole effectively lower viscosity of bronchial secretions may be questioned. Fever. Antipyretic analgesics (acetylsalicylic acid, acetaminophen, p. 198) are indicated only when there is high fever. Fever is a natural response and useful in monitoring the clinical course of an infection.

 

As “slow-reacting substances of anaphylaxis,” they are involved in allergic reactions; together with PG, they evoke the spectrum of characteristic inflammatory symptoms: redness, heat, swelling, and pain. Therapeutic applications. PG derivatives are used to induce labor or to interrupt gestation (p. 126); in the therapy of peptic ulcer, and in peripheral arterial disease.
Administration of (thiazide) diuretics offers a therapeutic approach of proven efficacy that is brought about by a decrease in circulating blood volume (decreased venous return) and peripheral resistance, i.e., afterload.

 

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