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Inhibitors of acid production. Acting on their respective receptors, the transmitter acetylcholine, the hormone gastrin, and histamine released intramucosally stimulate the parietal cells of the gastric mucosa to increase output of HCl. Histamine comes from enterochromaffin- like (ECL) cells; its release is stimulated by the vagus nerve (via M1 receptors) and hormonally by gastrin.
At 2 mg/kg, one out of 10 animals reacts; at 10 mg/kg, 5 out of 10 respond. The dose-frequency relationship results from the different sensitivity of individuals, which as a rule exhibits a log-normal distribution (C, graph at right, linear scale). |
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