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The most common unwanted effect is gastrointestinal upset (nausea, vomiting, diarrhea, etc. ) due to (1) a direct mucosal irritant action of these substances and (2) damage to the natural bacterial gut flora (broad-spectrum antibiotics) allowing colonization by pathogenic organisms, including Candida fungi.
It should be pointed out that neuroleptics do not exert an anticonvulsant action, on the contrary, they may lower seizure thershold. Because they inhibit the thermoregulatory center, neuroleptics can be employed for controlled hypothermia (p. 202). Adverse Effects. Clinically most important and therapy-limiting are extrapyramidal disturbances; these result from dopamine receptor blockade.

 

The time required for the eradication of dermatophytes corresponds to the renewal period of skin, hair, or nails. Griseofulvin may cause uncharacteristic adverse effects. The need for prolonged administration (several months), the incidence of side effects, and the availability of effective and safe alternatives have rendered griseofulvin therapeutically obsolete.
Lowering of pupillary sphincter tonus and pupillary dilation by local administration of homatropine or tropicamide (mydriatics) allows observation of the ocular fundus. For diagnostic uses, only short-term pupillary dilation is needed. The effect of both agents subsides quickly in comparison with that of atropine (duration of several days).

 

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