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According to one hypothesis, uptake into the hydrophobic interior of the plasmalemma of neurons results in inhibition of electrical excitability and impulse propagation in the brain. This concept would explain the correlation between anesthetic potency and lipophilicity of anesthetic drugs (A). However, an interaction with lipophilic domains of membrane proteins is also conceivable.
It contributes to the induction of cytokine production, including that of IL-2. The breakthroughs of modern transplantation medicine are largely attributable to the introduction of cyclosporin A. Prominent among its adverse effects are renal damage, hypertension, and hyperkalemia.

 

Desired effects. As anti-allergics, immunosuppressants, or anti-inflammatory drugs, glucocorticoids display excellent efficacy against “undesired” inflammatory reactions. Unwanted effects. With short-term use, glucocorticoids are practically free of adverse effects, even at the highest dosage.
Having entered the blood, drugs may bind to the protein molecules that are present in abundance, resulting in the formation of drug-protein complexes. Protein binding involves primarily albumin and, to a lesser extent, ?-globulins and acidic glycoproteins. Other plasma proteins serve specialized functions in connection with specific substances.

 

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