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According to one hypothesis, uptake into the hydrophobic interior of the plasmalemma of neurons results in inhibition of electrical excitability and impulse propagation in the brain. This concept would explain the correlation between anesthetic potency and lipophilicity of anesthetic drugs (A). However, an interaction with lipophilic domains of membrane proteins is also conceivable.
Desired effects. As anti-allergics, immunosuppressants, or anti-inflammatory drugs, glucocorticoids display excellent efficacy against “undesired” inflammatory reactions. Unwanted effects. With short-term use, glucocorticoids are practically free of adverse effects, even at the highest dosage. |
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