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Thus, excitation of the neuron leads to activation of a larger aggregate of effector cells, although the action of released norepinephrine may be confined to the region of each junction. Excitation of preganglionic neurons innervating the adrenal medulla causes a liberation of acetylcholine.
G-proteins can undergo lateral diffusion in the membrane; they are not assigned to individual receptor proteins. However, a relation exists between receptor types and G-protein types (B). Furthermore, the ?-subunits of individual G-proteins are distinct in terms of their affinity for different effector proteins, as well as the kind of influence exerted on the effector protein.

 

Risk factors are: premature menopause, physical inactivity, cigarette smoking, alcohol abuse, low body weight, and calcium-poor diet. Prophylaxis: Administration of estrogen can protect against postmenopausal loss of bone mass. Frequently, conjugated estrogens are used.
Biotransformation of these drugs involves cytochrome P450 (CYP 3A4) and is therefore subject to interaction with various other drugs inactivated via this route.

 

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